Effect of Systemic Isotretinoin Treatment on Depression and Other Psychological Symptoms: A Case-Control Study

Objective: Isotretinoin is highly preferred in the treatment of severe and resistant acne, but there are still disagreements about whether it has psychogenic side effects. In this study; we aim to investigate changes psychological symptoms before after a group patients treated with isotretinoin. Material Methods: A total 110 who had moderate or decided start isotretinoin treatment, were included. Acne Quality Life Scale, Beck Depression Inventory (BDI), Suicidal Ideation Symptom Check List (SCL-90-R) Psychological Screening tests performed compared starting at 6th month treatment. Results: our study, both pre-treatment post-treatment groups, rate risk for depression was significantly higher that acne (p<0.05). The scores psychiatric found be lower than those all parameters We have somatization, depression, phobic thoughts, general symptom index women associated improved quality life BDI male female (p=0.001). SCL-90-R obsession, sensitivity, anger, decreased Conclusion: Our study objectively demonstrated does not cause symptoms, even improves caused by life.